Microfilaria Infection in Metastatic Node in a Case of Breast Carcinoma.

Filariasis is a major public health problem in tropical and subtropical countries such as India. It is caused by nematodes, principally Wuchereria bancrofti and Brugia malayi and is transmitted by the Culex mosquito. W.bancrofti accounts for 90% of cases of lymphatic filariasis. Filaria of the breast with axillary lymphadenopathy and lymphedema, mimicking breast carcinoma has been previously reported. Microfilariae have also been previously observed as coincidental findings with various inflammatory and neoplastic lesions. Few examples are hemangiomas of the liver, meningiomas, intracranial hemangioblastomas, uterine cervix, pharyngeal, urinary bladder, preputial and metastatic carcinomas, melanomas, and leukemia.Here, we report an unusual case of filarial infection of a metastatic axillary node in a case of invasive breast carcinoma, observed in a modified radical mastectomy specimen. Previous cases reported in literature have reported microfilaria in metastatic axillary node detected on cytology specimens; histological diagnosis, though reported, is rare.

Variational approach to study soliton dynamics in a passive fiber loop resonator with coherently driven phase-modulated external field.

We report a detailed semianalytical treatment to investigate the dynamics of a single cavity soliton (CS) and two copropagating CSs separately in a Kerr mediated passive optical fiber resonator which is driven by a phase-modulated pump. The perturbation is dealt with by introducing Rayleigh's dissipation function in the framework of a variational principle that results in a set of coupled ordinary differential equations describing the evolution of individual soliton parameters. We further derive closed-form expressions for quick estimation of the temporal trajectory, drift velocity, and the phase shift accumulated by the CS due to the externally modulated pump. We also extend the variational approach to solve a two-soliton interaction problem in the absence as well as in the presence of the externally modulated field. In the absence of a phase-modulated field, the two copropagating solitons can attract, repulse, or propagate independently depending on their initial delay. The final state of interaction can be predicted through a second-order differential equation which is derived by the variational method. While in the presence of the phase-modulated field, the two-soliton interaction can result in annihilation, merging, breathing, or a two-soliton state depending on the detuning frequency and the pump power. Variational treatment analytically predicts these states and portrays the related dynamics that agrees with the full numerical simulation carried out by solving the normalized Lugiato-Lefever equation. The results obtained through this variational approach will enrich the understanding of complex pulse dynamics under a phase-modulated driving field in passive dissipative systems.

CD8-positive Mycosis Fungoides Masquerading as Pyoderma Gangrenosum.

Mycosis fungoides (MF), a primary cutaneous T-cell lymphoma, accounts for <1% of non-Hodgkin lymphomas. The diagnosis of classic MF is based on a constellation of typical clinical presentation, histopathology, immunohistochemistry, and T-cell monoclonality detected by molecular studies. Rarely, atypical clinical presentation may occur. The typical immunohistochemical phenotype is, CD2 +ve, CD3 +ve, CD5 +ve, CD4 +ve, and CD8 - ve. Here, we report a rare case of CD8 +ve MF in a 43-year-male patient who was clinically diagnosed as pyoderma gangrenosum initially. The atypical presentation and rarity of such case have prompted this report.

A clinicopathological study of mediastinal masses operated in a tertiary care hospital in Eastern India in 3 years with special reference to thymoma.

INTRODUCTION: The mediastinum is the central portion of the thoracic cavity, limited by pleural cavities laterally, thoracic inlet superiorly, and the diaphragm inferiorly. Housing numerous organs, it is a veritable Pandora's box, within which various lesions may develop. This study was conducted to assess the epidemiologic profile, clinicoradiological features, cytological, and histopathological findings in patients presenting with mediastinal masses in a tertiary care hospital over a period of 3 years. MATERIALS AND METHODS: This is a retrospective study of cases presenting with mediastinal masses attending the Cardiothoracic Surgery Department of Medical College, Kolkata between May 2011 and April 2014. Detailed history, physical, and radiological findings were noted. Fine needle aspiration cytology (FNAC) was performed when feasible. Following surgery, histopathological, and immunohistochemical (IHC) examinations of the specimens were undertaken. RESULTS: Of the 22 cases included in our study, ten were anterior, seven middle, and five posterior mediastinal masses. Fifteen cases were male and seven were female. Thymic pathology was detected in seven cases, lymphoma in five, extragonadal germ cell tumor (GCT) in three, schwannoma and pericardial cyst in two cases each and neurofibroma, ganglioneuroma, and retrosternal thyroid in one case each. The age group of the patients for each diagnostic category was found to be of significance. FNAC was done in 15 cases. IHC was required for classification of lymphoma cases (CD45, CD15, CD30, CD20, CD3, Tdt, CD34, and Ki-67). CONCLUSION: This study reflects the incidence of different mediastinal masses in West Bengal with their clinicopathologic correlation.